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The scary way diabetes affects the brain

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A growing body of research is finding that diabetes can take as devastating toll on the brain. And considering the alarming rate at which type 2 diabetes has increased this is particularly concerning. As of 2010 there were approximately 285 million people diagnosed with the disease compared to around 30 million in 1985.

A new study published this week in the journal Neurology shows that people with type 2 diabetes demonstrate a decline in cognitive skills and ability to perform daily activities over the course of only two years.

These changes are linked with an impaired ability to regulate blood flow in the brain, due in part to inflammation, which is commonly associated with type 2 diabetes.

A healthy brain distributes blood as needed to areas of increased neural activity. In diabetic individuals, however, this process becomes impaired.

“We have shown that people with diabetes have abnormal blood flow regulation in the brain, namely impaired ability to increase blood flow and deliver sugar and oxygen to the brain during episodes of increased mental activity,” said the study’s lead author, Dr. Vera Novak of the Harvard Medical School. “Inflammation further alters blood flow regulation in diabetic people and contributes to mental and functional decline.”

For the study, the researchers recruited 65 men and women with an average age of 66, half of whom had Type 2 diabetes and half of whom did not. The participants were given a series of memory and cognition tests at the outset of the study and again two years later. They also received brain scans to measure brain volume and blood flow and blood tests to measure inflammation and blood sugar control.

Here are some of the key findings:

After two years, the people with diabetes showed greater declines in gray matter as well as impairments in their ability to regulate blood flow in the brain than the people without.
Blood flow regulation decreased by an average of 65 percent in the participants with diabetes.
Among participants with diabetes, scores on thinking and memory tests decreased by an average of 12 percent, from 46 to 41 points, while test scores of the participants without diabetes stayed the same at 55 percent.
Higher levels of inflammation were correlated with greater difficulties with blood flow regulation.
Those with the highest levels of blood flow regulation impairment at the outset of the study had more difficulties performing daily activities (such as cooking and bathing) after two years.
The study is the latest to observe a link between diabetes and cognitive decline. With a growing body of research showing an association between insulin resistance and neurodegeneration, some scientists are even referring to Alzheimer’s Disease as “Type 3 diabetes.”

A new trial by Novak’s team is currently underway to determine whether injecting insulin into the brain might slow cognitive decline.

“Worse performance on daily activities, worse memory or slower gait speed in older diabetic adults may hallmark a decline in ability to regulate blood flow in the brain,” Novak said. “For older diabetic people it is important to maintain healthy lifestyle and minimize fluctuations of blood sugar levels, in addition to their medication regimen.”

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“The scary way diabetes affects the brain”