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Presenting The First Brain-Gene Interface: Thought-Controlled Protein Production

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You’ve heard about controlling robotic arms or prosthesis with thoughts, but what about genes? In a deceptively simple experiment, bioengineers in Switzerland combined a classical brain-computer interface with a biological implant, which effectively allowed a genetic switch to be operated by brain activity.

Imagine wearing a “funny” cap fitted with electrodes and a tiny implant, then controlling your mood by thinking the perfect “pure” thoughts that would cause a cascade of feel good chemicals. If it works, this could basically work as a painkiller, so you can deliver just the right amount. Really, there’s a lot of potential floating around this thing.

The setup went something like this: human participants wore a standard EEG cap that registered their brain activity, then a device translated this into a electrical signal and sent it to a electromagnetic field generator. Each specific kind of brain activity thus corresponded to a certain magnetic field. In the meantime, researchers tweaked bacterial genes into kidney cells to cause them to produce light-sensitive proteins. Then, the cells were bioengineered so when they sensed light these would produce a protein called secreted alkaline phosphatase (SEAP). The protein was chosen for no particular reason other than it is extremely easy to detect in the blood, so it fit well for demonstrative purposes. A mini-setup was made consisting of the engineered cells and a LED, all encased in a plastic pouch – this was inserted under the skin of several mice.

The human volunteers were tasked with various cognitive activities, like playing Minecraft or meditating. These activities generated a magnetic field which activated the implant’s infrared LED, triggering SEAP production. Playing Minecraft produced moderate levels of SEAP, while meditating resulted in high levels. Interestingly enough, a third group was thought to consciously light the LEDs on or off, thereby purposely turning SEAP production on or off (Nature Communications). As you can see, by using an implant, the setup harnesses the power of optogenetics without requiring the user to have his or her own cells genetically altered. We’ll definitely hear more about this in the future.

“Controlling genes in this way is completely new and is unique in its simplicity,” explains Martin Fussenegger, Professor of Biotechnology and Bioengineering at the Department of Biosystems (D-BSSE) in Basel.

Fussenegger hopes that a thought-controlled implant could one day help to combat neurological diseases, such as chronic headaches, back pain and epilepsy, by detecting specific brainwaves at an early stage and triggering and controlling the creation of certain agents in the implant at exactly the right time.

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“Presenting The First Brain-Gene Interface: Thought-Controlled Protein Production”